Invisible Intersex: How Discourse Serves to Perpetuate Violence

Critical discourse analysis surrounding intersex individuals makes it is clear that the violence against intersex individuals stems from a sense of othering due to the silence surrounding the public discussion and representation of intersex individuals. Additionally, the current discourse serves to create a circular argument of blame instead of serving to decrease the violence done upon intersex individuals. This research serves to explore the discourse surrounding intersex individuals and propose social and institutional ways of working to end the stigma surrounding intersexuality

The Myth of Neutrality: Linguistic Influence in the Integration of Nonbinary Identities in English and German

Grammatical structures that differ among languages can affect the way people of different cultures think, speak, and behave. Because of its close ties with identity, language also has the ability to manipulate the way people view themselves and others. Ethnographic research among English and German speakers shows that these differing grammatical structures affect the integration into society of nonbinary, intersex, and agender individuals through a grammatical predisposition for gender neutral language. As such, the means of increasing social integration of these groups also differs between linguistic and cultural borders

Comparative Oncologic and Toxicity Outcomes of Salvage Radical Prostatectomy Versus Nonsurgical Therapies for Radiorecurrent Prostate Cancer: A Meta-Regression Analysis.

CONTEXT: In the absence of randomised controlled trials comparing the oncologic, toxicity, and functional outcomes of salvage radical prostatectomy (SRP), salvage high-intensity focused ultrasound (SHIFU), salvage brachytherapy (SBT), and salvage cryotherapy (SCT), controversy exists as to the optimal salvage modality in radiorecurrent prostate cancer. OBJECTIVE: We carried out a meta-regression analysis to determine whether there is a difference in oncologic, toxicity, and functional outcomes using data from original publications of salvage modalities in the postradiation setting. EVIDENCE ACQUISITION: We performed a systematic review of PubMed/Medline citations according to the Preferred Reporting Items for Systematic Review and Meta-analysis (PRISMA) statement. We included 63 articles in the analysis (25 on SRP, 8 on SHIFU, 16 on SCT, 14 on SBT). EVIDENCE SYNTHESIS: Median values of the following variables were extracted from each study: patient age, length of follow-up, prostate-specific antigen (PSA) before radiotherapy (RT), PSA before salvage therapy, Gleason score before RT, and time interval between RT and salvage therapy. Functional, toxicity, and oncologic outcomes were measured according to rates of impotence, incontinence, fistula formation, urethral strictures, and biochemical recurrence. Meta-regression adjusting for confounders found no significant difference in oncologic outcomes between SRP and nonsurgical salvage modalities. SBT, SCT, and SHIFU appeared to have better continence outcomes than SRP. No significant difference in toxicity outcomes between modalities was found, although limitations such as reporting, selection, and publication bias and between-study heterogeneity must also be considered with these conclusions. CONCLUSIONS: Oncologic outcomes are comparable for SRP and all three nonsurgical salvage modalities. We found no significant differences in toxicity outcomes among modalities; however, SRP appears to be associated with worse rates of urinary incontinence than SBT, SCT, and SHIFU. PATIENT SUMMARY: We performed a meta-regression analysis to compare oncologic, functional, and toxicity outcomes between salvage radical prostatectomy and nonsurgical salvage modalities. Oncologic and toxicity outcomes appear to be similar; however, all nonsurgical salvage modalities may be associated with better continence outcomes.This is the author accepted manuscript. The final version is available from Elsevier via http://dx.doi.org/10.1016/j.euf.2015.09.00

Increased prevalence of irritable bowel syndrome in patients with bronchial asthma

AbstractIrritable bowel syndrome (IBS) is one of the most common diseases of the gastrointestinal tract. IBS may represent a primary disorder of gastrointestinal motility, accompanied with motor dysfunction in various extraintestinal sites. Recent studies suggest that IBS is associated with bronchial hyper-responsiveness and bronchial asthma might be more prevalent in IBS patients than in control subjects. The aim of our study was to assess the prevalence of IBS in a cohort of asthmatic patients. We evaluated 150 patients with bronchial asthma (71 males and 79 females, aged 45.1±14.9 years) and two control groups including 130 patients with other pulmonary disorder and 120 healthy subjects. All subjects enrolled (asthmatic and controls) completed the Greek version of the Bowel Disease Questionnaire (BDQ). BDQ is a, previously validated, self-report instrument to measure gastrointestinal symptoms. Diagnosis of IBS was based on Rome II criteria. The IBS prevalence was significantly higher in asthmatics (62/150, 41.3%) than in subjects with other pulmonary disorders (29/130, 22.3%,P <0.001) and healthy ones (25/120, 20.8%, P<0.001). For all subjects studied, the prevalence of IBS was significantly higher in females (78/214, 36.4%) than in males (38/186, 20.4%, P<0.001). The IBS prevalence in asthmatic males was 29.5% vs. 15.2% in male patients with other pulmonary disorders (P=0.002) and 14.2% in male healthy subjects (P=0.002). The IBS prevalence in asthmatic females was 51.8% vs. 28.1% in females patients with other pulmonary disorders (P<0.001) and 26.5% in females healthy subjects (P<0.001). None of the asthma medications were associated with increased or decreased likelihood of IBS. We conclude that patients with bronchial asthma have an increased prevalence of IBS. Further studies are needed to clarify the potential pathogenetic mechanisms underlying the association between IBS and asthma

Hiding Resources that Can Fail

In earlier work, we presented a process algebra, PACSR, that uses resource failures to capture probabilistic behavior in reactive systems. In this paper, we explore the effects of resource failures in the situation where resources may be hidden from the environment. For this purpose, we introduce a subset of PACSR, called PACSR-lite, that allows us to isolate the issues surrounding resource hiding, and we provide a sound and complete axiomatization of strong bisimulation for this fragment

Simulation and Verification in a Process Calculus for Spatially-Explicit Ecological Models

We propose PALPS, a Process Algebra with Locations for Population Systems. PALPS allows us to produce spatially-explicit individual-based ecological models and to reason about their behavior. PALPS has two abstraction levels: At the first level, we may define the behavior of an individual of a population and, at the second level, we may specify a system as the collection of individuals of various species located in space. In PALPS, the individuals move through their life cycle while changing their location and interact with each other in various ways such as predation, infection or mating. Furthermore, we propose a translation of a subset of PALPS into the probabilistic model checker PRISM. We illustrate our framework via models of dispersal in metapopulations and by applying PRISM on PALPS models for verifying temporal logic properties and conducting reachability and steady-state analysis

Controlling Reversibility in Reversing Petri Nets with Application to Wireless Communications

Petri nets are a formalism for modelling and reasoning about the behaviour of distributed systems. Recently, a reversible approach to Petri nets, Reversing Petri Nets (RPN), has been proposed, allowing transitions to be reversed spontaneously in or out of causal order. In this work we propose an approach for controlling the reversal of actions of an RPN, by associating transitions with conditions whose satisfaction/violation allows the execution of transitions in the forward/reversed direction, respectively. We illustrate the framework with a model of a novel, distributed algorithm for antenna selection in distributed antenna arrays.Comment: RC 201